Screening Services for Pre-Clinical Development of Neuro-Pharmaceuticals
NeuroProof as a contract research organization is a global leader and preferred partner in the field of microelectrode array (MEA)-based phenotypic screening of primary cultures. NeuroProof offers screening services and state-of-the-art mathematical expertise for the phenotypic analysis of test agents on neuronal network activity. The services comprise the growing of primary neuronal cultures on MEA chips, medium throughput screening of test agents, high quality recording of spontaneous and compound-induced network activity, state-of-the-art mathematical analyses, and sophisticated pattern recognition methods. The unique platform is well suited to identify and characterize effects of test agents on neuronal network activity and brain cell functioning.
Our company is specialized in the measurement of neuronal network activity via microelectrode arrays (MEA)-neurochips (). We have extensive experience with a range of primary neuronal cell cultures () and human neuronal stem cells, and with the recording and mathematical analysis of their spontaneous and compound-induced network activities.
Using our proprietary pattern recognition algorithms, we determine the similarity or difference of a compound to other known compounds.
This allows screening for differentiation from marketed compounds, mimicry of endogenous ligands, and assessment of synergistic effects. The cultures also allow to assess effects on neuronal maturation, synaptogenesis, and regenerative properties as well as assessing the differentiation process of human stem cells cultures.