Scientific Publications

Schroeder OHU., Schultz L., Knospe AM., Winkler M, Weiss DG, Jügelt K. “Human induced pluripotent stem cell-derived neuronal cell cultures in drug discovery and development”: In: Hock, F.J., Pugsley, M.K. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Cham. (2024), https://doi.org/10.1007/978-3-030-73317-9_3-1
Wohlrab, J., et al., Influence of Janus kinase inhibitors on the neuronal activity as proof-of-concept model for itch. Skin Pharmacology and Physiology, 2021.
Carbone, B. E., M. Abouleish, K. E. Watters, S. Vogel, A. Ribic, O. H. Schroeder, B. M. Bader and T. Biederer. "Synaptic Connectivity and Cortical Maturation Are Promoted by the Omega-3 Fatty Acid Docosahexaenoic Acid." Cereb Cortex, (2019).
Bader BM, Jügelt K, Schultz L, Schroeder OH-U. Ginkgo biloba L. (Ginkgoaceae) Leaf Extract Medications From Different Providers Exhibit Differential Functional Effects on Mouse Frontal Cortex Neuronal Networks. Frontiers in pharmacology. 2018;9(848).
Feng X, Bader BM, Yang F, Segura M, Schultz L, Schröder OHU, et al. Improvement of impaired electrical activity in NPC1 mutant cortical neurons upon DHPG stimulation detected by micro-electrode array. Brain Research. 2018;1694:87-93.
Bader, B. M., Steder, A., Klein, A. B., Frolund, B., Schroeder, O. H. U., & Jensen, A. A. (2017). Functional characterization of GABAA receptor-mediated modulation of cortical neuron network activity in microelectrode array recordings. PLoS One, 12(10), e0186147. doi: 10.1371/journal.pone.0186147
Gramowski-Voß A, Schwertle H-J, Pielka A-M, Schultz L, Steder A, Jügelt K, Axmann J, Pries W. Enhancement of cortical network activity in vitro and promotion of GABAergic neurogenesis by stimulation with an electromagnetic field with a 150 MHz carrier wave pulsed with an alternating 10 and 16 Hz modulation. Front. Neurol. 2015. 6:158. doi: 10.3389/fneur.2015.00158
Bellwon P, Culot M, Wilmes A, Schmidt T, Zurich MG, Schultz L, Schmal O, Gramowski-Voss A, Weiss DG, Jennings P, Bal-Price A, Testai E, Dekant W. Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood-brain barrier. Toxicol In Vitro. 2015 Feb 12. [Epub ahead of print]
Pomponio G, Zurich MG, Schultz L, Weiss DG, Romanelli L, Gramowski-Voss A, Di Consiglio E, Testai E. Amiodarone biokinetics, the formation of its major oxidative metabolite and neurotoxicity after acute and repeated exposure of brain cell cultures. Toxicol In Vitro. 2015 Feb 7. [Epub ahead of print]
Schultz L, Zurich MG, Culot M, Fabulas-da Costa A, Landry C, Bellwon P, Kristl T, Hörmann K, Ruzek S, Aiche S, Reinert K, Bielow C, Gosselet F, Cecchelli R, Huber CG, Schroeder OH, Gramowski-Voss A, Weiss DG, Bal-Price A. Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models. Toxicol In Vitro. 2015 May 27 [Epub ahead of print]
Hammer, Harriet; Bader, Benjamin M.; Ehnert, C; Bundgaard, C; Bunch, Lennart; Hoestgaard-Jensen, Kirsten; Schröder, Olaf O-H; Bastlund, Jesper F; Gramowski-Voß, A; Jensen, Anders A. A multifaceted GABAA receptor modulator: Functional properties and mechanism of action of the sedative-hypnotic and recreational drug methaqualone (Quaalude®). Molecular Pharmacology, 2015 Jun 8. pii: mol.115.099291.
Parenti C, Turnaturi R, Aricò G, Gramowski-Voss A, Schroeder OH, Marrazzo A, Prezzavento O, Ronsisvalle S, Scoto GM, Ronsisvalle G, Pasquinucci L. The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures. Neuropharmacology 2013 Aug;71:70-82.
Vandormael B, Fourla DD, Gramowski-Voß A, Kosson P, Weiss DG, Schröder OH, Lipkowski A, Georgoussi Z, Tourwé D. Superpotent [Dmt(1)]Dermorphin Tetrapeptides Containing the 4-Aminotetrahydro-2-benzazepin-3-one Scaffold with Mixed mu Opioid Receptor Agonistic Properties. J Med Chem. 2011 Nov 24;54(22):7848-59.
Gramowski A, Jügelt K, Schröder OH, Weiss DG, Mitzner S. Acute functional neurotoxicity of lanthanum(III) in primary cortical networks. Toxicol Sci. 2011 Mar;120(1):173-83.
Novellino A, Scelfo B, Palosaari T, Price A, Sobanski T, Shafer TJ, Johnstone AF, Gross GW, Gramowski A, Schroeder O, Jügelt K, Chiappalone M, Benfenati F, Martinoia S, Tedesco MT, Defranchi E, D'Angelo P, Whelan M. Development of micro-electrode array based tests for neurotoxicity: assessment of interlaboratory reproducibility with neuroactive chemicals. Front Neuroeng. 2011 Apr 27;4:4.
Gramowski A, Flossdorf J, Bhattacharya K, Jonas L, Lantow M, Rahman Q, Schiffmann D, Weiss DG, Dopp E. Nanoparticles Induce Changes of the Electrical Activity of Neuronal Networks on Microelectrode Array Neurochips. Environ Health Perspect. 2010 Oct;118(10):1363-9.
Johnstone AFM, Gross GW, Weiss DG, Schroeder OH, Gramowski A, Shafer TJ. Microelectrode arrays: A physiologically based neurotoxicity testing platform for the 21st century. Neurotoxicology 2010 Aug;31(4):331-50.
Kirazov E., Kirazov, L., Schroeder, O., Gramowski, A., Vassileva, E., Naydenov, C., Weiss, D.G. Amyloid beta peptides exhibit functional neurotoxicity to cortical network cultures. Compt. Rend. Acad. bulg. Sci. 2008;61(7):94-99.
Gramowski, A., Jügelt, K., Stüwe, S., Schulze, R., McGregor, G.P., Wartenberg-Demand, A., Loock, J., Schröder, O., Weis, D.G.: Functional Screening of Traditional Antidepressants with Primary Cortical Neuronal Networks Grown on Multielectrode Neurochips. European Journal of Neurosciences. 2006 Jul;24(2):455-65.
Gramowski A, Stüwe S, Jügelt K, Schiffmann D, Loock J, Gross GW, Schröder O, Weiss DG.: Detecting neurotoxicity through electrical activity changes of neuronal networks on microelectrode neurochips. ALTEX. 2006;23:410-415
Gross GW, Dian EA, Keefer EW, Gramowski A, Stuewe S.: Long-term functional contact between nerve cell networks and microelectrode arrays. In: Toward Replacement Parts for the Brain: Implantable Biomimetic Electronics as Neural Prostheses. Burger T, Glanzman D (eds.). 2005;177-204. MIT Press.
Gramowski, A., Jügelt, K., Weiss, D.G., Gross, G.W.: Substance identification by quantitative characterization of oscillatory activity in murine spinal cord networks on microelectrode arrays. Eur J Neurosci. 2004 May;19(10):2815-25.
Mitzner, S., Loock, J., Peszynski, P., Klammt, S., Majcher-Peszynska, J., Gramowski, A., Stange, J., Schmidt, R.: Improvement in central nervous system functions during treatment of liver failure with albumin dialysis MARS- a review of clinical, biochemical and electrophysiological data. Metabolic Brain Disease. 2002 Dec;17(4):463-75.
Keefer, E.W., Gramowski, A., Stenger, D.A., Pancrazio, J.J., Gross, G.W.: Characterization of acute neurotoxic effects of trimethylopropane phosphate via neuronal network biosensors. Biosensors & Bioelectronics. 2001 Sep;16(7-8):513-25.
Loock, J., Stange, J., Mitzner, S., Schmidt, R., Gramowski, A., Schiffmann, D., Weiss, D.G., Keefer, E., Gross, G.W.: Influence of albumine dialysis (MARS) on neuronal network activity in vitro - early results. German Journal of Gastroenterology. 2001 Jun;39 Suppl 2:28-32.
Keefer, E.W., Gramowski, A., Gross, G.W.: Presynaptic control of synchronized periodic oscillations in neuronal populations. J Neurophysiol. 2001;86:3030-3042.
Gramowski, A., Schiffmann, D., Gross, G.W. Quantification of acute neurotoxic effects of trimethyltin using neuronal networks cultured on microelectrode arrays. NeuroToxicology. 2000 Jun;21(3):331-42.
Gross, G.W., Norton, S., Gopal, K., Schiffmann, D., Gramowski, A.: Nerve cell network in vitro: Applications to neurotoxicology, drug development, and biosensors. Cellular Engineering. 1997;2:138-147.
Feng X., Bader B.M., Yang F., Segura M., Schultz L., Schroeder O.H.U., et al. Improvement of impaired electrical activity in NPC1 mutant cortical neurons upon DHPG stimulation detected by micro-electrode array. Brain Research. 2018;1694:87-93.