Neuroscience CRO Services

NeuroProof offers innovative services for phenotypic screening using neuronal cell cultures. Leveraging microelectrode array technology and sophisticated data analysis, we provide functional phenotypic screenings.

Key Points:

• Predictivity: Our phenotypic screening with complex neuronal cell cultures demonstrates unparalleled predictivity of therapeutic or neurotoxic effects.
• Excellent Quality: As leaders in the field, we deliver high-quality results based on rigorous standards, fast turnaround times, exceptional customer service, and extensive experience from thousands of experiments.
• Innovation: Innovation is at the core of our business. We strive for a balance between innovation and result reliability, with a mission to develop screening services that lead to breakthroughs in healthcare.
• Experience: Recognized for our expertise in MEA recordings and cell culture models, we've executed hundreds of projects with clients across North America, Europe, and Asia.

Disease Models

NeuroProof offers a diverse range of disease models for neurodegenerative diseases, psychotic disorders, and rare diseases. Our models include primary mouse or human iPSC-derived neurons, with options for standard or unique in-house developed models.

Neurotoxicity

Our neurotoxicity assays address safety pharmacology and environmental toxin assessment needs. We also develop custom neurotoxicity assays, catering to specific requirements such as for CAR-T cell therapy.

Prediction of Side Effects

Our assays support effective prediction of side effects during preclinical testing. For instance, our seizure assay accurately evaluates seizure-causing effects of new drugs, crucial for risk assessment in drug development.

MEA Recording Services

We conduct compound testing using microelectrode array recordings and advanced data analysis. Our services include concentration response curve generation, substance database comparison, long-term experiments, and assessment of compound synergies. For MEA recordings we use the Maestro MEA System from Axion Biosystems.

We offer a standardized test protocol with short turn around time and at attractive costs. Ask us for our standard screening offer.

Imaging

Automated imaging services complement our offerings, providing higher throughput phenotypic screening at affordable costs.

Stem Cell Services

With extensive experience in iPSC-derived neuronal cell cultures, particularly on MEA plates, we've collaborated on numerous projects with academic and commercial partners to optimize neuronal stem cell culture protocols. Our expertise is available as a standalone service.

Biologics and AAV Testing

Gene therapies will change the paradigm in future medicine. Adeno-associated virus constructs and other biologicals will uniquely impact curing fatal diseases. We test AAV constructs in disease modeling or test AAV libraries as a service.

Data Analysis Services

As leaders in spike train analysis, we offer comprehensive data analysis services for MEA recordings.

Projects

NeuroProof is your ideal partner for CNS drug screening projects. From assay development to complex screening campaigns, we manage every aspect of the project, including human iPSC cell line development, assay construction, optimization, and execution. We perform test for fee services and milestone based projects.