Receptor target validation

In many examples, we have demonstrated receptor validation with standard pharmacology methods. For this, we pretreat cultures with a confirmed antagonist of a specific receptor and test a compound in an MEA experiment to see if this pretreatment neutralizes the compound effect.

We also offer target validation in our disease models or with our cell culture systems. Our target validation delivers valuable data for your preclinical research programs and additional data for your clinical phase II trials to assess the therapeutic relevance of your drug targets in orthogonal assays.

Our parallel screening in our complex cell systems from murine or human sources with functional electrophysiological, molecular, and genetic read-outs will improve your drug development projects with robust data for expected clinical efficacy.

For target validation in specific disease areas, we have developed a broad range of disease models. Or we offer specific disease models with iPSC derived neuronal cells from patients.

With our Electrophysiological MEA read-outs, we can assess the functional effect of a potential treatment, which is vital for predicted efficacy. Ask us for a prospective study plan.

We combine our molecular read-outs with our MEA data and data from identical probes.

With this, we can perform an in-depth analysis with our AI technologies for a pathway analysis and compare the effects on your targets with those of our databases.

We offer the following read-outs and tools:

Receptor pharmacology with a confirmed antagonist
Western Blotting
ELISA assay
shRNA interference
screening with patient iPSC-derived neuronal cell cultures
Immunostaining and microscopy
Genetic expression profiles with RNA sequencing from whole-cell culture
or with single-cell RNA sequencing
Pathway analysis with our AI tools.