Neurotoxicity

The human brain is the most complex organ in the universe. Its vulnerability to neurotoxins poses a significant threat to our life and health. Neurotoxins can act acutely, like a snake bite, or over long periods, such as pesticides causing neurodegenerative diseases. Drug abuse remains one of the greatest challenges in society.

NeuroProof has developed a broad range of in vitro tools to assess neurotoxicity. Utilizing our in vitro assays with primary neuronal cell cultures from mice, rats, and human iPSC-derived cell cultures, we offer precise assays to evaluate specific neurotoxic threats.

Acute Neurotoxicity

Our MEA screening approach is used to detect acute neurotoxicity. NeuroProof has tested many hazardous compounds, including TTX and botulinum toxin. These compounds have drastic effects even at low concentrations, impacting different receptors and pathways, such as sodium ion channels or synaptic vesicle protein release. Our methods detect these effects within seconds to minutes, with resolution across different concentrations, crucial for assessing potential threats.

Developmental Neurotoxicity

Developmental neurotoxic effects can impact an entire human life. Embryonic infections can affect newborns through maternal immune activation and other mechanisms. In young infants, certain neurotoxins pose significant hazards. Our in vitro assays with primary cell cultures mimic the full developmental process, from embryonic to mature stages, enabling us to assess these threats comprehensively.

Chronic Toxic Effects

Certain compounds or infections cause chronic effects. We have evaluated the impact of cytokine storms and the effects of repeated compound application on chronic toxicity.

Drug Side Effects

Drugs can have unwanted side effects. In drug development, one of the most significant issues is seizure-inducing side effects. NeuroProof has developed a new approach using machine learning algorithms to assess potential seizure effects at various concentrations. A similar method is applied to evaluate the sedative effects of compounds.

Addiction

Addiction is a complex phenomenon that leads to drug abuse. One mechanism associated with addiction is the desensitization of a compound's action. Our assays help in understanding and assessing this complex process.

Contact Us

For further information on our neurotoxicology services, please contact us. 

Contact us for further information!

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